René Wardenaar

This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.

This study shows that chromosome 7 gain optimizes WNT signaling in colorectal cancer by counteracting excessive stemness from APC mutations.

The paper shows that chromosomal instability (CIN) leads to distinct p21-expressing cell populations with different cell-cycle recovery and extracellular vesicle (EV) properties, resulting in increased migration.

This study shows that TET loss of function promotes aneuploidy, particularly chromosome 17 trisomy, which provides a proliferative advantage in iNKT cells and mESCs.

This study shows that chromosomal instability in TNBC increases EV secretion and promotes cell migration via EFEMP1, identifying EFEMP1 as a potential therapeutic target.

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study characterizes tertiary lymphoid structures in endometrial cancer using multi-level transcriptomics, identifying transcriptional signatures and immune cell dynamics linked to ICI response.

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

This study identifies four subgroups of osteosarcomas based on genomic and transcriptomic analysis, revealing distinct mechanisms of CDK4 amplification in relation to MDM2 or TP53 alterations.

This study shows that IFNγ treatment reduces apoptosis and improves translation rates in ALS6 patient-derived motor neurons under oxidative stress.

The paper identifies DNA copy number alterations and chromosome-scale losses caused by replication stress in non-transformed cells, revealing their role in chromosomal instability and cancer evolution.

METHimpute constructs complete methylomes from low-coverage WGBS data using a Hidden Markov Model, achieving high accuracy at 6X coverage compared to 60X.