Angela Wieland

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

The paper identifies adaptation strategies in aneuploid cancer cells through in vitro evolution and multi-omics analysis, revealing key transcription factors and genomic changes that improve proliferation and survival.

The paper investigates the effects of monosomy in human cells, finding that it impairs proliferation and genomic stability, with partial gene dosage compensation and ribosome biogenesis stress contributing to p53 pathway activation.