DET1 dynamics underlie co-operative ubiquitination by CRL4DET1 COP1 complexes
Abigail E. Burgess, Tarren A. Loughran, Liam S. Turk, Hunter G. Nyvall, Jessica L. Dunlop, Sam A. Jamieson, Jack R. Curry, John E. Burke, Pavel Filipčík, Simon H. J. Brown, Peter D. Mace
The paper reports the cryo-EM structure of human DET1 in complex with DDB1-DDA1 and Ube2e2, revealing how DET1 dynamics facilitate COP1 recruitment and ubiquitination.
Science Advances · Feb 26, 2025Peer-reviewedBiochemistry