Pavel Filipčík

This study shows that narrow-beam geometry in cryo-EM reduces radiation damage and improves signal-to-noise ratio by capturing diffraction patterns from biological specimens.

This study uses cryo-EM to resolve microtubule structures in different nucleotide states, revealing how GTP hydrolysis affects lattice stability and microtubule dynamics.

The paper shows that human mitochondrial Lon protease degrades substrates starting from either terminus, with unidirectional processing, and provides structural and biochemical evidence for this mechanism.

The paper introduces MiCSPARC, a cryo-EM pipeline for microtubule structure determination, achieving high-resolution reconstructions of decorated and undecorated microtubules.

The paper reports the cryo-EM structure of human DET1 in complex with DDB1-DDA1 and Ube2e2, revealing how DET1 dynamics facilitate COP1 recruitment and ubiquitination.

DiffGAN estimates missing phases in single molecule cryo-electron diffraction data to determine protein structures at atomic resolution using a conditional GAN.