Proteome-wide landscape of solubility limits in a bacterial cell
Ádám Györkei, Lejla Daruka, Dávid Balogh, Erika Őszi, Zoltán Magyar, Balázs Szappanos, Gergely Fekete, Mónika Fuxreiter, Péter Horváth, Csaba Pál, Bálint Kintses, Balázs Papp
The paper systematically investigates solubility limits of Escherichia coli proteins upon overexpression, revealing that most insoluble proteins aggregate after folding and that high disorder content and low surface stickiness correlate with solubility.
Scientific Reports · Apr 21, 2022Peer-reviewedMolecular Biology