Mónika Fuxreiter

This study identifies Arc as critical for packaging tau into extracellular vesicles, facilitating its release and intercellular transmission in Alzheimer's disease.

This study identifies the glycine-arginine-rich motif of 53BP1 as essential for RNA interactions and phase separation during DNA damage response, showing its role in DNA repair.

The paper proposes a model for collective interactions in biomolecular condensates that describes dynamic clusters and their material properties.

This study shows Arc EVs mediate intercellular synaptic plasticity through IRSp53-dependent biogenesis, leading to loss of surface AMPA receptors in neighboring dendrites.

The paper systematically investigates solubility limits of Escherichia coli proteins upon overexpression, revealing that most insoluble proteins aggregate after folding and that high disorder content and low surface stickiness correlate with solubility.

The paper shows that disordered proteins in fuzzy complexes retain residual frustration, leading to interaction versatility with different partners.

The paper predicts droplet-promoting proteins in the human proteome using FuzDrop, concluding most proteins can undergo liquid-liquid phase separation.

The paper shows that α-synuclein forms liquid droplets that mature into amyloid-rich hydrogels, suggesting Lewy body formation is linked to arrested maturation in the presence of lipids.

The paper uses a computational framework to show that linker dynamics regulate the phase transition and aggregation propensity of biomolecular condensates, with implications for pathological fibrillization.