Lejla Daruka

A preclinical resistance framework discovers the virulence risks of antibiotics in development

The paper develops a framework to assess antibiotic resistance and virulence risks in pathogens, finding that resistance can increase virulence through genetic changes.

Pathogen genomic surveillance as a scalable framework for precision phage therapy

This paper develops a scalable framework for precision phage therapy by combining genomic surveillance and phage typing to target carbapenem-resistant Acinetobacter baumannii.

Proteome-wide landscape of solubility limits in a bacterial cell

The paper systematically investigates solubility limits of Escherichia coli proteins upon overexpression, revealing that most insoluble proteins aggregate after folding and that high disorder content and low surface stickiness correlate with solubility.

Cotranslational assembly imposes evolutionary constraints on homomeric proteins

The paper shows that homomeric proteins tend to have interfaces near the C-terminus, which is favorable for cotranslational assembly and reduces misassembly.