Author

Yongna Xing

University of Wisconsin–MadisonORCID 0000-0002-9834-528XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aguilera Paula· 1 shared Alan Michael PittmaniD· 1 shared Anna C. ThomasiD· 1 shared Catherine A HarwoodiD· 1 shared Cheng-Guo WuiD· 1 shared Cristina CarreraiD· 1 shared Dagan JenkinsiD· 1 shared DALE A. MOULDINGiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenomics

Aguilera Paula

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2 papers

Recent·Most cited

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

Michael S. O’Connor, Cheng-Guo Wu, Yichong Lao, Yongna Xing, Xuhui Huang

This paper investigates the activation mechanism of PP2A-B56δ by analyzing disease variant E198K using cryo-EM and computational methods, revealing progressive loosening of the N/C-arm interface as the activation pathway.

bioRxiv · Aug 23, 2026 · PreprintBiophysics

Inherited duplications of PPP2R3B promote naevi and melanoma via a novel C21orf91-driven proliferative phenotype

Satyamaanasa Polubothu, Lara Al-Olabi, Daniël A. Lionarons, Mark Harland, Anna C. Thomas, Stuart D. Horswell, Lilian Hunt, Nathan Wlodarchak, Aguilera Paula, Sarah Brand, Dale Bryant, Philip L. Beales, Cristina Carrera, Hui Chen, Greg S Elgar, , Veronica A. Kinsler

This study identifies inherited PPP2R3B duplications as a melanoma predisposing factor, revealing a C21orf91-driven proliferative phenotype in melanocytes.

Genetics in Medicine · Jun 18, 2021Peer-reviewedGenomics