DALE A. MOULDING

This study investigates how mechanical loading affects MSC proliferation in the coronal suture, finding that five loading sessions are needed for a clear increase in proliferation, with effects lasting up to 24 hours.

The paper develops a nanobody-based method to label kidney lymphatic vessels in mice, revealing spatially restricted LYVE1 expression unique to the kidney.

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

The paper develops an ex vivo chick embryonic bone model using PLGA microparticles to study growth factor delivery effects on cell differentiation and tissue formation, showing that controlled release of BMP2 and FGF2 alters collagen deposition and cell morphology.

This study identifies two progenitor sources for kidney lymphatics in mice: Tie2 endothelial lineage and Osr1 intermediate mesoderm, showing a dual origin for kidney lymphatic formation.

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

The paper establishes a humanized neuronal model to investigate the effects of manganese dysregulation on neuronal function and disease mechanisms.

This study shows that clodronate liposomes enhance lentiviral liver transduction but not AAV or LNP-mRNA in mice.

This study shows that neonatal injury increases microglial phagocytosis of GABAergic synapses in the spinal dorsal horn, leading to long-term structural changes and altered responses to adult re-injury.

The paper investigates endosomal structure and APP biology in Down syndrome mouse models and finds no alterations in endosome number, size, or APP processing.

This study identifies inherited PPP2R3B duplications as a melanoma predisposing factor, revealing a C21orf91-driven proliferative phenotype in melanocytes.

The paper shows that neuro-mesodermal progenitors in mice express T/Brachyury but not Sox2, challenging the hypothesis that they co-express both markers.