Author

Latifa Zekri

German Cancer Research CenterORCID 0000-0002-9844-7948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ariane Metzger· 1 shared Gundram JungiD· 1 shared Helmut Rainer SalihiD· 1 shared Ilona Hagelstein· 1 shared Jonas S. HeitmanniD· 1 shared Josef LeiboldiD· 1 shared Karolin Schwartz· 1 shared Martin PflügleriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Ariane Metzger

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1 paper

Recent·Most cited

Bivalent bispecific CD28 antibodies reinforce T-cell responsiveness and revert anergy/quiescence in patients treated with bispecific CD3 antibodies

Latifa Zekri, Natalie Köhler, Ariane Metzger, Nisha Prakash, Jonas S. Heitmann, Monika Engel, Timo Manz, Stefanie Müller, Sebastian Hörner, Karolin Schwartz, Melissa Zwick, Ilona Hagelstein, Nadine Brückner, Martin Pflügler, Josef Leibold, , Helmut Rainer Salih

This paper develops bispecific costimulators (BiCos) that restore T-cell function in patients treated with bispecific CD3 antibodies, reversing anergy and quiescence through enhanced signaling.

bioRxiv · Sep 20, 2026 · PreprintImmunology