Author

Ariane Metzger

University of Freiburg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Melanie BoerriesiD· 2 shared Angelika Bettina HarbaueriD· 1 shared Benjamin Chun‐Kit TongiD· 1 shared Gundram JungiD· 1 shared Helmut Rainer SalihiD· 1 shared Ilona Hagelstein· 1 shared Inmaculada SeguraiD· 1 shared Jonas S. HeitmanniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Melanie BoerriesORCID

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2 papers

Recent·Most cited

Bivalent bispecific CD28 antibodies reinforce T-cell responsiveness and revert anergy/quiescence in patients treated with bispecific CD3 antibodies

Latifa Zekri, Natalie Köhler, Ariane Metzger, Nisha Prakash, Jonas S. Heitmann, Monika Engel, Timo Manz, Stefanie Müller, Sebastian Hörner, Karolin Schwartz, Melissa Zwick, Ilona Hagelstein, Nadine Brückner, Martin Pflügler, Josef Leibold, , Helmut Rainer Salih

This paper develops bispecific costimulators (BiCos) that restore T-cell function in patients treated with bispecific CD3 antibodies, reversing anergy and quiescence through enhanced signaling.

bioRxiv · Sep 20, 2026 · PreprintImmunology

A physiological Na+ signal activates mitochondrial PINK1 to couple synaptic depression to caspase-3-dependent spine pruning

Benjamin Chun‐Kit Tong, Inmaculada Segura, Simone Wanderoy, Markus Rehm, Ariane Metzger, Melanie Boerries, Angelika Bettina Harbauer

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.

bioRxiv · May 31, 2026 · PreprintNeuroscience