Liuh‐Yow Chen

The paper shows orphan nuclear receptors recruit TRIM28 to increase H3K9me3 at telomeres, promoting the alternative lengthening of telomeres pathway in human cells.

This study identifies histone H3.3 as essential for telomere dysfunction-induced cGAS-STING pathway activation and telomere fusion.

This study shows that orphan nuclear receptors promote the ALT telomere maintenance mechanism by forming APBs and enabling telomeric DNA synthesis.