Long Nam Nguyen

This study determines the cryo-EM structure of MFSD2B bound to S1P and identifies its transport mechanism through mutagenesis and simulations.

This study shows that blood-borne sphingosine 1-phosphate (S1P) maintains vascular resistance and cardiac function through albumin-S1P and myocyte S1PR signaling in mice.

The paper identifies biallelic FLVCR1 variants causing a range of neurodevelopmental and neurodegenerative disorders, linking them to choline and ethanolamine transport dysfunction.

This study shows that Mfsd2b and Spns2 are essential for embryonic vascular development and vascular homeostasis, and their loss leads to severe hemorrhage and anaphylaxis susceptibility.