Yu L. Lei

This study identifies IL-1β-inducing pathobionts in Crohn's disease that drive inflammation and may predict response to anti-TNF therapies.

This study identifies a SOX2-CCL2-IL1 pathway that drives immune suppression in precancerous epithelial dysplasia, promoting malignant transformation.

The paper introduces a GAN-based method to generate high-quality membranes for cells with poor staining in fluorescent microscopy images, improving segmentation accuracy.

The paper introduces a large-scale spatial transcriptomic dataset and a Graph Neural Network-based method for cell type deconvolution in human immuno-oncology.

supCPM improves scRNA-seq visualization by preserving global structure and cluster variance using supervised clustering guidance.

FARDEEP improves tumor-infiltrating lymphocyte deconvolution by using least trimmed squares to reduce outliers, providing more accurate immune cell composition estimates.