Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism
Yuanzhong Pan, Tsu-Pei Chiu, Lili Zhou, Priscilla Chan, Tia Tyrsett Kuo, Francesca Battaglin, Shivani Soni, Priya Jayachandran, Jingyi Jessica Li, Heinz‐Josef Lenz, Shannon M. Mumenthaler, Remo Rohs, Evanthia T. Roussos Torres, Steve A. Kay
This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.
bioRxiv · Apr 26, 2024 · PreprintCancer Biology