Methylome profiling of SetDB1 deficient ESCs reveals diverse epigenetic cross-talk during pluripotency
Nick G.P. Bovee, Stefan H. A. Hoogland, Ehsan Habibi, Siebren Frölich, Arie B. Brinkman, Klaas W. Mulder, Joop H. Jansen, Matthew C. Lorincz, Henk G. Stunnenberg, Hendrik Marks
This study investigates DNA methylation changes in SetDB1-deficient mouse ESCs, revealing its role in silencing retrotransposons and imprinted regions through coordination with H3K9me3.
bioRxiv · Jun 18, 2025 · PreprintMolecular Biology