This study identifies 21 infertility loci and over 400 reproductive hormone loci through GWAS across multiple cohorts, finding limited genetic correlation between reproductive hormones and infertility.

Nature Genetics · Apr 14, 2025Peer-reviewedGenetic & Genomic Medicine

From Biobanking to Personalized Medicine: the journey of the Estonian Biobank

Lili A. Milani, Maris Alver, Sven Laur, Sulev Reisberg, Toomas Haller, Oliver Aasmets, Erik Abner, Helene Alavere, Annely Allik, Tarmo Annilo, Krista Fischer, Georgi Hudjashov, Maarja Jõeloo, Mart Kals, Liis Karo-Astover, , Andres Metspalu

The paper reviews the Estonian Biobank's role in advancing genomics research and personalized medicine through its comprehensive data and translational focus.

medRxiv · Sep 22, 2024 · PreprintGenetic & Genomic Medicine

Uncovering the Shared Genetic Components of Thyroid Disorders and Reproductive Health

Jéssica Figuerêdo, Kristi Krebs, Natàlia Pujol‐Gualdo, Toomas Haller, Urmo Võsa, Vallo Volke, Triin Laisk, Reedik Mägi, Andres Metspalu, Lili A. Milani, Tõnu Esko, Mari Nelis, Georgi Hudjashov, Raivo Kolde, Sven Laur, , Jaak Vilo

This study identifies shared genetic components between thyroid disorders and reproductive health using GWAS and genetic correlation analysis in 743,088 individuals.

European Journal of Endocrinology · Jul 27, 2024Peer-reviewedGenetic & Genomic Medicine

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

Kristi Krebs, Jonas Bovijn, Neil S. Zheng, Maarja Lepamets, Jenny C. Censin, Tuuli Jürgenson, Dage Särg, Erik Abner, Triin Laisk, Yang Luo, Line Skotte, Frank Geller, Bjarke Feenstra, Wei Wang, Adam Auton, , João Fadista

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.

The American Journal of Human Genetics · Sep 3, 2020Peer-reviewedGenetics