Systems BiologybioRxivPreprint
Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Saravanan Subramaniam, Marc Arthur Napoleon, Saran Lotfollahzadeh…·Vipul Chimanlal Chitalia
This study identifies the Kyn-AHR-TF axis as a prothrombotic pathway in SARS-CoV-2 infection, showing increased kynurenine and AHR activation in mice and humans.