Florian Douam

Male and female mice achieve equivalent protection against heterologous SARS-CoV-2 infection through divergent immune mechanisms

The paper shows that male and female mice achieve similar protection against a different SARS-CoV-2 strain through distinct immune mechanisms, with sex-specific roles for T-cells and inflammation.

The type I and III interferon responses restrict infection with tick-borne orthoflaviviruses through IFI6

This study identifies IFI6 as a key antiviral effector mediating type I and III interferon restriction of tick-borne orthoflaviviruses in human cells and mice.

Sub-phenotypes of pneumonia defined by pulmonary histopathological features

The paper defines sub-phenotypes of pneumonia using histopathological features from human lung samples and validates them in mouse models.

A Mouse Model of SARS-CoV-2-Driven Acute Maladaptive Responses and Chronic Systemic Diseases

The paper develops a mouse model that exhibits severe SARS-CoV-2 infection and post-acute systemic diseases, revealing molecular mechanisms of PASC.

Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2

This study identifies the Kyn-AHR-TF axis as a prothrombotic pathway in SARS-CoV-2 infection, showing increased kynurenine and AHR activation in mice and humans.

Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.