Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease
Kelley E. Anderson, Linh My Tran, Kostyantyn Krysan…·Jennifer Beane
This study identifies four molecular archetypes of lung adenocarcinoma premalignant lesions using bulk RNA and exome sequencing, linking proliferation-associated features to aggressive tumor outcomes.