Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Saravanan Subramaniam, Marc Arthur Napoleon, Saran Lotfollahzadeh, Mohamed Hassan Kamel, Hengky Kurniawan, Murad Elsadawi, Devin Kenney, Florian Douam, Markus Bosmann, Stephen A. Whelan, Howard Cabral, Eric Burks, Grace Zhao, Vijaya B. Kolachalama, Katya Ravid, Vipul Chimanlal Chitalia
This study identifies the Kyn-AHR-TF axis as a prothrombotic pathway in SARS-CoV-2 infection, showing increased kynurenine and AHR activation in mice and humans.
bioRxiv · Jan 17, 2025 · PreprintSystems Biology