Nicole Calakos

Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice

The paper edits a specific class of chemical synapses in a genetic OCD mouse model to prevent excessive grooming behavior.

DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response

The paper introduces a transgenic mouse line, DIO-SPOTlight, to monitor ISR-regulated protein synthesis in specific cell types across the CNS and other organ systems.

Non-monotonic effects of GABAergic synaptic inputs on neuronal firing

This paper investigates how GABAergic synaptic inputs can have non-monotonic effects on neuronal firing, showing both excitatory and inhibitory behaviors depending on the reversal potential and input strength.

DYT-TOR1A Subcellular Proteomics Reveals Selective Vulnerability of the Nuclear Proteome to Cell Stress

This study uses subcellular proteomics to show that DYT-TOR1A mutant cells have greater nuclear proteome disruption under stress compared to other conditions.

Rare Variant Burden in Known Dystonia Genes in Population Controls and Sporadic Dystonia Patients

The paper analyzes rare variants in dystonia genes in population controls and sporadic dystonia patients to assess their clinical relevance.

Striatal fast-spiking interneurons drive habitual behavior

This study identifies fast-spiking interneurons in the striatum as key drivers of habitual behavior through circuit-level modulation of spiny projection neurons.