Henry H. Yin

This paper introduces a dual-color miniature endoscope for simultaneous calcium imaging of two neuronal populations in behaving mice, revealing direction-dependent activity patterns in striatal neurons.

This study shows that the SNr dynamically controls skilled forelimb movement by modulating kinematics in real time through brief pauses or bursts.

This study uses optogenetics in mice to show that parafascicular nucleus stimulation affects skeletomotor, autonomic, and aversive behaviors, suggesting its role in integrating behavioral state feedback and motor control.

This study identifies a cortical circuit involving ACC-D1+ neurons critical for initiating goal-directed movements and shows its therapeutic potential in Parkinsonian akinesia.

This study identifies how striatal pathways control action counting and steering through optogenetic manipulation and calcium imaging in mice.

This study identifies modular striatal dynamics and reciprocal inhibition in mice performing a water-reaching task, showing how these mechanisms coordinate sequential actions.

This study shows that A2A-positive neurons in the NAc core regulate effort exertion by bidirectional modulation of lever pressing behavior in an effort-dependent manner.

This study identifies distinct VTA GABA neurons that regulate force vectors during motivated behavior through precise force tuning and optogenetic manipulation.

This study shows that reducing midline thalamus neuron bursting prevents absence seizures in a mouse model by enhancing vigilance and suppressing seizure activity.

This study shows that TSP1 and TSP2 from astrocytes are essential for synapse development and effort control during operant conditioning in mice.

This study selectively stimulates STN projection neurons in mice and shows that STN output directly controls movement parameters with high precision.

This study shows that phasic dopamine signaling in VTA neurons regulates force exertion during learning, not reward prediction error.

The paper identifies a locus coeruleus-hippocampal dopamine pathway involved in operant reinforcement by showing D1+ dentate gyrus neurons mediate self-stimulation through optogenetic activation.

The paper identifies a novel circuit regulating neurogenesis and cellular proliferation in the ventral subventricular zone through glutamatergic inputs and local interneurons.

The paper introduces a new system for simultaneous calcium imaging and optogenetic stimulation in freely moving mice, demonstrating its ability to image and activate specific neurons and recreate behavior.

This paper presents a quadrupedal robot that achieves natural locomotion through a neurally inspired hierarchical control system without training or internal models.

This study shows that training-induced excitatory synaptogenesis in the ACC->DMS circuit is required for effort control, not learning, and is mediated by the 2{delta}-1 protein.

This study investigates the role of the mediodorsal thalamus in timing behavior using an operant temporal production task in mice, finding that its inactivation impairs timing accuracy and precision.

This study shows that VTA dopamine neurons bidirectionally control impulse vector and anticipatory behavior during motivated actions.

This study investigates the roles of striatonigral and striatopallidal pathways in action performance and timing using optogenetic stimulation in mice.

This paper introduces a head-fixation system with load cells to continuously monitor force generated by mice during behavior, revealing previously neglected movement dynamics and correlating them with neural activity.

This study identifies three distinct populations of VTA GABAergic neurons that encode rotational head movements during target pursuit, with their activity disrupted during reward consumption.

This study identifies a thalamo-subthalamic pathway involved in movement initiation and shows that stimulating this pathway can rescue Parkinsonian symptoms in mice.

This study identifies a striatal interneuron circuit where parvalbumin-positive fast-spiking interneurons represent target distance and regulate striatal projection neuron activity to modulate movement velocity during pursuit behavior.

This study identifies a hypothalamic-extended amygdala circuit that regulates temporal discounting by modulating motivational signals through AgRP neurons and Y1R activation.

This paper identifies a cellular mechanism involving giant ankyrin-B that leads to stochastic axon projections and contributes to neurodiversity and ASD.

This study identifies fast-spiking interneurons in the striatum as key drivers of habitual behavior through circuit-level modulation of spiny projection neurons.