Synthetic BiologybioRxivPreprint
DNA-templated spatially controlled proteolysis targeting chimeras for CyclinD1-CDK4/6 complex protein degradation
Rong Zheng, Abhay Prasad, Deeksha Satyabola…·Hao Yan
This paper introduces DNA-templated PROTACs (DTACs) that enable precise spatial control over protein degradation, showing enhanced selectivity and potency in degrading the CyclinD1-CDK4/6 complex.