Yang Xu

LNP Delivery of Prime Editors Enables Durable Correction of PAH R408W in Phenylketonuria Models

This paper demonstrates the use of LNP-delivered prime editors to correct the PAH R408W mutation in PKU models, achieving ~50% correction efficiency.

The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

Emergence of rigidity percolation and critical behavior in tunable protein condensates

This study investigates how protein condensates transition from liquid-like to networked states through tunable interactions, revealing critical behavior and percolation transitions linked to biological function.

Ferrapoptosis: Discovery of a Hybrid Programmed Cell Death

This paper defines and validates a new form of cell death called Ferrapoptosis, which combines features of ferroptosis and apoptosis in traumatic brain injury, and identifies Smg7 as a key regulator.

Loops, TADs, Compartments, and Territories are Elastic and Robust to Dramatic Nuclear Volume Swelling

The paper investigates how genome structure responds to nuclear swelling, finding that global topology remains elastic and robust despite dramatic volume changes.

Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in HLRCC

This study identifies ROS-induced oxidation of PTPN12 as the mechanism underlying ABL1 phosphorylation in HLRCC-associated PRCC.

Mapping Human Hematopoietic Hierarchy At Single Cell Resolution By Microwell-seq

The paper develops Microwell-seq, a high-throughput scRNA-seq platform, to construct a single-cell resolution transcriptome atlas of human hematopoietic differentiation, revealing a revised hierarchy without oligopotent progenitors.

Natural Variation in Arabidopsis Cvi-0 Accession Uncovers Regulation of Guard Cell CO2 Signaling by MPK12

The paper identifies a single amino acid substitution in MPK12 causing ozone hypersensitivity and stomatal CO2-insensitivity in Arabidopsis, revealing MPK12's role as an inhibitor of HT1 in guard cell CO2 signaling.