Author

Rong Zheng

Arizona State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genomics· 1 Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:CRISPR screen· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Abhay PrasadiD· 1 shared Bo Yang· 1 shared Botao LiuiD· 1 shared Dandan GengiD· 1 shared Dapeng LiiD· 1 shared Deeksha SatyabolaiD· 1 shared Fan ZhangiD· 1 shared Hao YaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperSynthetic Biology

Abhay PrasadORCID

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3 papers

Recent·Most cited

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

Rong Zheng, Zhike Lu, Rongwei Wei, Young-Cheul Shin, Jiang Du, Qingfeng Zhang, Jianbo Li, Xiaoqi Wang, Yi Wei, Botao Liu, Yang Chen, Lihong Ding, Heng Zhang, Hui Chen, Jing Huang, Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

Nature Structural & Molecular Biology · Mar 18, 2026Peer-reviewedGenomics

Cerebellin-2 neurons in the parafascicular thalamic nucleus regulate self-grooming behavior

Li Zhang, Huimeng Song, Yaning Li, Huaxin Zhang, Shibo Diao, Dandan Geng, Zijie Zhao, Bo Yang, Rong Zheng, Zekun Li, Lei Wang, Tianyun Zhang, Yingyue Jiang, Zining Liu, Lexuan Zhang, , Peng Cao

This study identifies Cbln2+ neurons in the parafascicular thalamic nucleus as regulators of self-grooming behavior, showing bidirectional control and potential for non-invasive OCD treatment.

bioRxiv · Mar 22, 2025 · PreprintNeuroscience

DNA-templated spatially controlled proteolysis targeting chimeras for CyclinD1-CDK4/6 complex protein degradation

Rong Zheng, Abhay Prasad, Deeksha Satyabola, Yang Xu, Hao Yan

This paper introduces DNA-templated PROTACs (DTACs) that enable precise spatial control over protein degradation, showing enhanced selectivity and potency in degrading the CyclinD1-CDK4/6 complex.

bioRxiv · Sep 18, 2024 · PreprintSynthetic Biology