Takashi Sutani

The paper investigates how ESCO2-mediated acetylation of cohesin is distributed and retained across the genome, revealing region-specific patterns and post-replicative retention mechanisms.

This study shows cohesin regulates multiple transcription steps, with loss leading to reduced induction but minimal steady-state expression changes.

This study shows that Wpl1 and Eco1 regulate Scc2-cohesin interaction to limit DNA loop expansion and ensure proper mitotic chromosome segregation.

This study identifies Smc5/6's role in organizing transcription-induced positive DNA supercoils by initiating loop extrusion at cohesin-dependent boundaries.