Camilla Björkegren

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.

This study identifies Smc5/6's role in organizing transcription-induced positive DNA supercoils by initiating loop extrusion at cohesin-dependent boundaries.

This study shows that transcription and replication create chromosome loop boundaries by blocking cohesin progression, shaping S-phase chromosomes in yeast.