Author

Kristian E. Jeppsson

Karolinska InstitutetORCID 0000-0002-4085-9771Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 3 Approach:experimental assay· 3 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Katsuhiko ShirahigeiD· 3 shared Toyonori Sakata· 3 shared Camilla Björkegren· 2 shared Ryuichiro NakatoiD· 2 shared Aditi KaushikiD· 1 shared Alba Ayats-FraileiD· 1 shared Alejandro M. MartiniD· 1 shared Andres Hernandez Maduro· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Katsuhiko ShirahigeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

DNA catenation is essential for Sister Chromatid Cohesion

Aditi Kaushik, Alba Ayats-Fraile, Vanessa Viera, Alejandro M. Martin, Andres Hernandez Maduro, James Collier, Toyonori Sakata, Jumpei Fukute, Katsuhiko Shirahige, Kristian E. Jeppsson, Raquel A Oliveira, Joaquím Roca, Madhusudhan Srinivasan

This study shows DNA catenation is essential for sister chromatid cohesion in budding yeast and metazoan chromosomes, as it provides force resistance necessary for accurate chromosome segregation.

bioRxiv · Jul 17, 2026 · PreprintMolecular Biology

Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils

Kristian E. Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide G. Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, Camilla Björkegren

This study identifies Smc5/6's role in organizing transcription-induced positive DNA supercoils by initiating loop extrusion at cohesin-dependent boundaries.

Molecular Cell · Jan 30, 2024Peer-reviewedMolecular Biology

Transcription and replication organize cohesin-dependent chromosome loops

Kristian E. Jeppsson, Toyonori Sakata, Ryuichiro Nakato, Stefina Milanova, Katsuhiko Shirahige, Camilla Björkegren

This study shows that transcription and replication create chromosome loop boundaries by blocking cohesin progression, shaping S-phase chromosomes in yeast.

Science Advances · Jun 10, 2022Peer-reviewedMolecular Biology