Author

Mark A. Hallen

Toyota Technological Institute at ChicagoORCID 0000-0002-9973-7509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Approach:optimal transport· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Adegoke A. OjewoleiD· 1 shared Adi Xiyal MukundiD· 1 shared Anna U. LowegardiD· 1 shared Bruce Randall DonaldiD· 1 shared David Zhou· 1 shared Elizabeth Dowd· 1 shared Graham T. HoltiD· 1 shared Hunter M. NisonoffiD· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Adegoke A. OjewoleORCID

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2 papers

Recent·Most cited

BioinformaticsProteins Structure Function and BioinformaticsPeer-reviewedOct 31, 2018

PLUG (Pruning of Local Unrealistic Geometries) removes restrictions on biophysical modeling for protein design

Mark A. Hallen

PLUG improves protein design by removing biophysical model restrictions through conformational pruning, achieving effectiveness comparable to DEE for larger designs.

3 citations

protein structurestatistical model

𝕏 PostBluesky

BioinformaticsJournal of Computational ChemistryPeer-reviewedOct 14, 2018

OSPREY 3.0: Open-Source Protein Redesign for You, with Powerful New Features

Mark A. Hallen, Jeffrey W. Martin, Adegoke A. Ojewole…·Bruce Randall Donald

OSPREY 3.0 improves protein design software with faster algorithms, GPU support, and a Python interface, showing accurate mutation effect predictions on protein-protein binding.

72 citations

protein structurestatistical model

𝕏 PostBluesky