Jeannine A. Frei

The paper identifies two small molecules that lower PrP levels in cultured cells but show limited activity in human cell lines and in vivo.

The paper assesses the cell-type-specific activity of intrathecally delivered antisense oligonucleotides in deep brain regions of non-human primates, finding broad target engagement across neuronal and non-neuronal cells.

This study investigates the role of cadherin-11 in autism by analyzing its expression and function in mouse models and human tissue, finding altered expression and synaptic changes in autism-associated conditions.

This study shows that Endoglycan negatively regulates cell-cell adhesion, affecting axon guidance and neuronal migration in the central nervous system.

This study shows that tomosyn regulates RhoA activity to maintain dendritic stability and AMPA receptor surface expression, with autism-associated variants disrupting this function.