Shiyong Huang

The paper shows that monocular deprivation in mouse visual cortex causes an all-or-none elimination of pyramidal cell connections to parvalbumin-positive interneurons, which is necessary for ocular dominance plasticity.

The paper identifies a parvalbumin-positive subtype of Purkinje neurons with distinct firing properties and shows that ion channel differences contribute to firing diversity.

This study investigates the role of cadherin-11 in autism by analyzing its expression and function in mouse models and human tissue, finding altered expression and synaptic changes in autism-associated conditions.

This study shows that conditional Pten knockout in PV- or Sst-expressing GABAergic neurons in mice leads to autism-related behavioral phenotypes.

This paper demonstrates that neuromodulators can induce bidirectional shifts in visual cortical responses through a pull-push mechanism in vivo.

This study shows that tomosyn regulates RhoA activity to maintain dendritic stability and AMPA receptor surface expression, with autism-associated variants disrupting this function.

The paper shows that inhibitory synapses in PV-INs recover resources dynamically, enabling linear rate encoding and controlling cortical visual response gain.