Margaret Windy McNerney

Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster

This study compares mitochondrial and oxidative stress signatures in spaceflight and Tauopathy using Drosophila melanogaster RNA-seq data to identify conserved pathways relevant to Alzheimer's disease.

The Social Cognition Paradox in Long-Duration Spaceflight: A VEN Fatigue Hypothesis for Duration-Dependent Emotion Recognition Decline

The paper proposes a VEN Fatigue Hypothesis to explain duration-dependent emotion recognition decline in long-duration spaceflight, supported by multi-omics and neuroimaging data.

Next-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput

GoDig 2.0 improves targeted proteomics by increasing multiplexing, efficiency, and target coverage, enabling analysis of post-translational modifications and compound-protein interactions.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Visualizing the Costs and Benefits of Correcting P-Values for Multiple Hypothesis Testing in Omics Data

The paper models and visualizes the costs and benefits of p-value correction for multiple hypothesis testing in omics data using simulated experiments and an interactive R Shiny application.

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.