Lisa M. Monteggia

The paper shows that inhibiting GABAB receptors in neurons unlocks dormant synapses on cancer cells, increasing neurotransmitter release and promoting tumor proliferation.

The paper uses a fluorescent glutamate sensor to show that evoked and spontaneous neurotransmission differ in their subsynaptic organization, with evoked release being clustered and spontaneous release being more diffuse.

This study shows that synaptic vesicle retrieval after single-vesicle fusion is not dependent on dynamin, despite a reduction in overall neurotransmission and vesicle numbers.