Natalí L. Chanaday

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

The paper compares lysosomal repair mechanisms in neurons and astrocytes, finding astrocytes use more robust ESCRT and RAB7-GAP pathways for lysosomal repair.

Glycosyltransferases regulate the expression of Golgi phosphoprotein 3 (GOLPH3)

The paper shows that GGT N-terminal domains regulate GOLPH3 expression, with implications for tumor progression and potential therapeutic applications.

Sparse delivery of Synaptobrevin-2 to neurons using extracellular vesicles

This study tracks Syb2-containing extracellular vesicles in neurons to reveal their endocytic pathways and rapid incorporation into synaptic vesicles.

Pseudouridine selects RNAs for extracellular transport

The paper identifies pseudouridine as a key modification enabling RNA extracellular transport and identifies MYL6 as a binding protein required for this process.

Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

Probing the segregation of evoked and spontaneous neurotransmission via photobleaching and recovery of a fluorescent glutamate sensor

The paper uses a fluorescent glutamate sensor to show that evoked and spontaneous neurotransmission differ in their subsynaptic organization, with evoked release being clustered and spontaneous release being more diffuse.

Persistence of quantal synaptic vesicle recycling following dynamin depletion

This study shows that synaptic vesicle retrieval after single-vesicle fusion is not dependent on dynamin, despite a reduction in overall neurotransmission and vesicle numbers.