Ege T. Kavalali

This paper investigates how specific synaptotagmin-1 mutations disrupt neurotransmission and synaptic plasticity by introducing phosphorylation sites and altering interactions with SNAP-25.

The paper shows that inhibiting GABAB receptors in neurons unlocks dormant synapses on cancer cells, increasing neurotransmitter release and promoting tumor proliferation.

This study uses DIA proteomics to analyze age-related changes in proteostasis and UPR dynamics in human neurons and mouse glia co-cultures, revealing cell-type-specific aging responses.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

The paper uses a fluorescent glutamate sensor to show that evoked and spontaneous neurotransmission differ in their subsynaptic organization, with evoked release being clustered and spontaneous release being more diffuse.

This study identifies SLM interneurons that modulate hippocampal activity to switch between memory encoding and retrieval modes.

The paper investigates glutamate spread in the neuropil using optical reporters and finds that glutamate can activate AMPA and NMDA receptors at distances up to 2 micrometers from the release site.

This study shows that synaptic vesicle retrieval after single-vesicle fusion is not dependent on dynamin, despite a reduction in overall neurotransmission and vesicle numbers.