BioengineeringSkeletal MusclePeer-reviewed
Distinct pathogenic influence of anti-HMGCR+ and anti-SRP+ immune-mediated necrotizing myopathy autoantibodies on engineered muscle function
Heta Lad, Yekaterina Tiper, Ernest Myguel Esteban…·Penney M. Gilbert
This study shows that anti-HMGCR and anti-SRP autoantibodies from IMNM patients have distinct direct effects on engineered muscle function, with anti-HMGCR reducing contractile force and anti-SRP causing atrophy without affecting force.
6 citations