Yekaterina Tiper

Distinct pathogenic influence of anti-HMGCR+ and anti-SRP+ immune-mediated necrotizing myopathy autoantibodies on engineered muscle function

This study shows that anti-HMGCR and anti-SRP autoantibodies from IMNM patients have distinct direct effects on engineered muscle function, with anti-HMGCR reducing contractile force and anti-SRP causing atrophy without affecting force.

Stable isotope tracer captures the anabolic response of human skeletal muscle microtissues undetected by puromycin labeling

This study compares stable isotope tracers and puromycin labeling in measuring muscle protein synthesis in engineered skeletal muscle, finding tracers detect anabolic responses missed by puromycin.

Elevated GLUT4 Levels in Human Skeletal Muscle Microtissues is Accompanied by Functional Insulin Dependence

This study compares GLUT4 and GLUT1 expression in 2D myotubes and 3D microtissues, finding higher GLUT4 levels in microtissues but insulin dependency limiting their use for T2D modeling.