Rebecca D. Huffstutler

The paper defines the role of smooth muscle cells in ECM remodeling during human wound healing and identifies TIMP1 as a key factor in effective repair.

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

This study shows ACAT1 regulates type I interferon via epigenetic control by linking fatty acid metabolism to histone acetylation in macrophages.