Pharmacology & ToxicologybioRxivPreprint
A conserved mechanism of LRRC8 channel inhibition by distinct drugs
Toshiki Yamada, Paola Bisignano, Erkan Karakaş, Jerod S. Denton
This study investigates how zafirlukast and pranlukast inhibit LRRC8 channels by identifying their binding sites and showing they destabilize the channel pore.
DOI 10.1101/2025.02.24.639894