Author

Erkan Karakaş

Vanderbilt UniversityORCID 0000-0001-6552-3185Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Caifeng Liu· 1 shared Jerod S. DentoniD· 1 shared Paola BisignanoiD· 1 shared Qingyu TangiD· 1 shared Toshiki YamadaiD· 1 shared Yu-Jing LaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

Caifeng Liu

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 1, 2026

Conformational landscape and clustering of human type 2 IP3 receptor in lipid nanodiscs

Caifeng Liu, Yu-Jing Lan, Qingyu Tang, Erkan Karakaş

The paper determines cryo-EM structures of human IP3R-2 in different conformations and clusters, revealing ligand interactions and subtype-specific features.

1 citation

humancryo-EM

Pharmacology & ToxicologybioRxivPreprintFeb 24, 2025

A conserved mechanism of LRRC8 channel inhibition by distinct drugs

Toshiki Yamada, Paola Bisignano, Erkan Karakaş, Jerod S. Denton

This study investigates how zafirlukast and pranlukast inhibit LRRC8 channels by identifying their binding sites and showing they destabilize the channel pore.

DOI 10.1101/2025.02.24.639894

electrophysiologydeep learning