Molecular BiologyNature BiotechnologyPeer-reviewed
Loss of transgene expression limits liver gene therapy in primates
Jenny A. Greig, Kelly M. Martins, Camilo Ayala Breton…·James M. Wilson
This study shows that transgene expression in primate liver declines rapidly after initial transduction, even though vector DNA remains in the nucleus, suggesting that genomic integration may be needed for durable expression.
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