James M. Wilson

This study develops a combinatorial chemistry approach to create biodegradable ionizable lipids for efficient mRNA delivery and gene editing in vivo.

This study shows that transgene expression in primate liver declines rapidly after initial transduction, even though vector DNA remains in the nucleus, suggesting that genomic integration may be needed for durable expression.

This paper evaluates an ACE2 decoy inhibitor that remains effective against SARS-CoV-2 variants including Omicron BA.1 and BA.2, and shows broad activity against related sarbecoviruses.

This paper demonstrates an intranasal gene therapy approach using an affinity-matured ACE2 decoy protein to prevent SARS-CoV-2 infection and its variants in animal models.