Diane Hoffman–Kim

This study uses 3D cortical microtissues to monitor microglia dynamics across maturation and inflammatory responses, showing changes in morphology, surveillance, and injury response.

This paper introduces a 3D cortical spheroid model to study ischemic brain injury and demonstrates its utility for screening stroke therapeutics.

The paper uses iPSC-derived neurons from Christianson syndrome patients to show allele-specific responses to rescue strategies, highlighting the need for personalized therapeutic approaches.

This study shows that rodent cortical spheroids exhibit network activity, including oscillations, and can be used for high-throughput network-perturbing experiments.

The paper quantifies DA neuron subtypes generated from mouse ESCs and finds higher production of calbindin+ subtype compared to calretinin+ subtype, with no effect from SHH and FGF8.