Diptatanu Das

ExPert infers causal perturbations from cell states by learning prototypes across 12 contexts, achieving high recall with low compute and validating findings in disease models.

The paper identifies dysregulated RNA splicing in alcohol-associated liver disease as a cause of regeneration failure, highlighting ESRP2 deficiency and its impact on key signaling pathways.

This study identifies the ESRP2-miR-122 axis as critical for postnatal liver polyploidization and maturation through RNA processing and cytokinesis regulation.