Ullas Valiya Chembazhi

This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

This study shows that mechanical-nuclear signaling in alveolar fibroblasts influences lung regeneration by modulating transcriptional identity and epithelial repair after injury.

This study shows that alveolar epithelial type I cells propagate mechanical signals that affect lung homeostasis and disease states through intercellular communication.

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

The paper identifies dysregulated RNA splicing in alcohol-associated liver disease as a cause of regeneration failure, highlighting ESRP2 deficiency and its impact on key signaling pathways.

The paper identifies PTBP1's role in regulating alternative splicing of actin regulators to control Sertoli cell actin cytoskeleton dynamics during spermatogenesis.

This study identifies the ESRP2-miR-122 axis as critical for postnatal liver polyploidization and maturation through RNA processing and cytokinesis regulation.

This study identifies PTBP1 as essential for intestinal stem cell survival and stemness by regulating gene expression through post-transcriptional mechanisms.

This study shows that DM1 mice have altered drug metabolism and increased fatty liver disease susceptibility due to RNA sequestration and splicing changes.

This study uses single-cell transcriptomics to track liver cell transitions during regeneration, revealing metabolic and proliferative dynamics in mouse liver.

The paper introduces SimiC, a method for inferring gene regulatory networks per cell phenotype and comparing them across conditions, revealing regulatory dynamics missed by single GRN approaches.