Author

Mariam Ordyan

Salk Institute for Biological StudiesORCID 0000-0003-0064-2997Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2

Frequent Co-Authors

Mary B. KennedyiD· 2 shared Padmini RangamaniiD· 2 shared Terrence J. Sejnowski A BiD· 2 shared Thomas M. BartoliD· 1 shared Tom Bartol· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersNeuroscience

Mary B. KennedyORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 2, 2024

A spatial model of autophosphorylation of Ca2+/calmodulin-dependent proteinkinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction ofsynaptic plasticity is greatly prolonged by CaM-trapping.

Thomas M. Bartol, Mariam Ordyan, Terrence J. Sejnowski A B…·Mary B. Kennedy

The paper develops a spatial model of CaMKII autophosphorylation in synaptic spines to show that CaM-trapping prolongs phospho-CaMKII lifetime by hindering dephosphorylation.

2 citations

statistical model

𝕏 PostBluesky

NeurosciencePLoS Computational BiologyPeer-reviewedJul 17, 2020

Interactions between calmodulin and neurogranin govern the dynamics of CaMKII as a leaky integrator

Mariam Ordyan, Tom Bartol, Mary B. Kennedy…·Terrence J. Sejnowski A B

This paper uses rule-based modeling to show that neurogranin modulates CaMKII phosphorylation dynamics, acting as a leaky integrator of calcium signals through interactions with calmodulin and phosphatase.

31 citations

statistical model

𝕏 PostBluesky