Evolutionary BiologybioRxivPreprint
A high aneuploidy supply rate underlies parallel evolution of fluconazole resistance in Saccharomyces cerevisiae
Saaz Sakrikar, Akriti Agrawal, Ina Suresh, David Gresham
This study shows that high spontaneous aneuploidy rates, not drug-induced mutations, drive fluconazole resistance in yeast through chromosome duplication at ERG11.
DOI 10.64898/2026.07.12.738117