Author

Tim James

Evotec (Germany)ORCID 0000-0003-0087-4130Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Adriana BorowaiD· 1 shared Agata Zaremba· 1 shared Alán F MuñoziD· 1 shared Alexandr A. KalininiD· 1 shared Amandine Thibaudeau· 1 shared Amélie Weiss· 1 shared Amy B. GoodaleiD· 1 shared Andrei Y. ZinovyeviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Adriana BorowaORCID

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2 papers

Recent·Most cited

BioinformaticsNature MethodsPeer-reviewedAug 1, 2025

Morphological map of under- and over-expression of genes in human cells

Srinivas Niranj Chandrasekaran, Eric Alix, John Arévalo…·Anne Elizabeth Carpenter

The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.

17 citationstop 3%

humanimaging

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 2, 2024

PIRATE: Plundering AlphaFold Predictions to Automate Protein Engineering

Graham M. Richardson, Jola Kopec, Carmen Esposito, Tim James

PIRATE uses surrogate models trained on AlphaFold2 predictions to rapidly assess disorder in proteins and improve sensitivity to point mutants in disorder prediction.

1 citation

protein structuredeep learning

𝕏 PostBluesky