Molecular BiologybioRxivPreprint
Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration
Hirotaka Iijima, Gabrielle G. Gilmer, Kai Wang…·Fabrisia Ambrosio
This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.